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This course aims to provide students with the fundamental principles of pharmacology in drug discovery and development. Topics include (1) protein structure, receptor theory, enzyme kinetics, and cell signalling pathways; (2) drug absorption, distribution, metabolism, elimination, and toxicity (3) key aspects of drug discovery, such as target selection and validation, identification of early lead compounds, optimization of leads into compounds suitable for pre-clinical development; (4) key stages and challenges in progressing from discovery to clinical development, and medical and economical consideration that may impact the progress of a drug discovery program; (5) enabling technologies in drug discovery: high throughput screening, structure-based drug design, molecular modelling, pharmaceutical profiling, and translational medicine. To enhance the understanding of basic principles of pharmacology in drug discovery and development, the students will participate in journal article discussions and critical evaluation of examples of successful or failed drug development, in addition to guided readings and lectures.