Decellularized Tissue-Microuidic Model Mimicking CTC Attachment to Epithelial Cells for the evaluation of Organ specic Metastasis
Tissue engineering has advanced with the development of decellularization techniques, particularly perfusion protocols, which remove cells while preserving the intricate extracellular matrix (ECM) of organs. This is crucial for replicating organ microenvironments. When decellularized tissues are combined with microfluidic technology, we create a model to simulate the process of circulating tumor cells (CTCs) adhering to endothelial cells, a critical step in metastasis. Decellularization preserves over 98% of organ growth factors and cytokines. We believe our Decellularization Microfluidic Organ (DMO) model can be utilized for therapeutics, mechanistic studies, or clinical diagnostic services, facilitating the broader adoption of personalized medical technologies.
Team members
Mr He Qiuyang (PhD (BME, 2026), City University of Hong Kong)
* Person-in-charge
(Info based on the team's application form)